Enhanced targeting of stem-like solid tumor cells with radiation and natural killer cells
نویسندگان
چکیده
منابع مشابه
Natural killer cell immunotherapy to target stem-like tumor cells
Advances in cancer immunotherapy are leading to its increasing and successful application for the treatment of solid-tissue cancers. Despite the recent advances there are still significant barriers, in particular, evidence for significant tumor heterogeneity, both genetic and epigenetic that limit long-term efficacy. Subpopulations of "stem-like" tumor cells have been identified in nearly all h...
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Breast cancer is the most common cancer among women worldwide. Every year, nearly 1.4 million new cases of breast cancer are diagnosed, and about 450.000 women die of the disease. Approximately 15-25% of breast cancer cases exhibit increased quantities of the trans-membrane receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2) on the tumor cell surface. Previous studies showe...
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Cancer stem cells (CSCs) are a rare population of cancer cells which have been shown to be capable of resisting conventional therapies, such as chemotherapy and radiation. Their persistence following therapeutic intervention, coupled with their stem like nature, endows these cells with the ability to repopulate the tumor, leading to eventual tumor relapse. Previously, it has been shown that the...
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Natural killer (NK) cells play an important role in the innate immune response against cancer, in particular in the elimination of tumor metastases and small tumors. NK cell-mediated control of large solid tumors is usually not efficient, although tumors often express high amounts of activating ligands and low levels of inhibitory ligands, such as MHC class I. Thus, we assume that these tumors ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2015
ISSN: 2162-402X
DOI: 10.1080/2162402x.2015.1036212